Phloroglucinol-enhanced whey protein isolate hydrogels with antimicrobial activity for tissue engineering

Aging populations in developed countries will increase the demand for implantable materials to support tissue regeneration. Whey Protein Isolate (WPI), derived from dairy industry by-products, can be processed into hydrogels with following desirable properties applications engineering: (i) ability adhesion and growth of cells; (ii) ease sterilization by autoclaving (iii) incorporation poorly water-soluble drugs antimicrobial activity, such as phloroglucinol (PG), fundamental phenolic subunit marine polyphenols. In this study, WPI were enriched PG at concentrations between 0 20% w/v. solubilization is far higher than water. Enrichment did not adversely affect mechanical properties, endowed activity against a range bacteria which occur healthcare-associated infections (HAI). WPI-PG supported of, collagen production human dental pulp stem cells - lesser extent osteosarcoma-derived MG-63 cells. summary, enrichment may promising strategy prevent microbial contamination while still promoting cell attachment growth.